Applications

It’s only impossible until it isn’t.

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Scores of applications now powered by a single touch.
That’s the Onyx™ platform in action.

Genome Discovery

Uncover novel biology, identify new pathways, discover genotype-phenotype relationships and regulatory circuits. Generate libraries with a variety of edits including insertions, deletions, and swaps across E. coli and yeast genomes.

Pathway Engineering

Engineer metabolic pathways for better outcomes and optimize strains for better phenotypes. Target both native and heterologous genome-integrated pathways for editing.

Heterologous Models

Understand the biology of higher eukaryotes—including humans and plants—through yeast as a model system. Create large-scale variation in human disease genes expressed in yeast to elucidate their impact on phenotypes. Edit plant genes expressed in yeast to define synthetic pathways and increase production of high-value compounds.

Access the richness of the entire genetic landscape

Build libraries with diverse edit types including insertions, deletions and swaps in coding and non-coding regions across the Escherichia coli and Saccharomyces cerevisiae genomes. Explore a wide variety of phenotypes with edited libraries, either in pools of cells or in isolated cells.

  • Massively parallel single edits
    • 100 – 10,000 edits
  • Greater than 30% expected edit efficiency
    • 15% — 75% depending on design library parameters
  • Greater than 70% library coverage for designs at all plexities
  • Massively parallel, precision edit payload:
    • Insertions: up to ~60 bp
    • Deletions: up to ~75 bp
    • Swaps: up to ~60 bp
E. coli

Readily available consumables kits for use with strains related to E. coli K‑12 strain MG1655 and B strain BL21:

  • Single edits kit delivers reagents for creation of libraries with one edit per cell.
  • Combinatorial edits kit delivers reagents for creation of libraries with several edits per cell.
S. cerevisiae

Readily available consumables kits for use with strains related to yeast S. cerevisiae strain S288c:

  • Single edits kit delivers reagents for creation of libraries with one edit per cell.
  • Combinatorial edits kit delivers reagents for creation of libraries with several edits per cell.

In addition to specific strains supported by Inscripta™, the Onyx platform may allow you to edit other strains of E. coli and S. cerevisiae. Please reach out with any questions.

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