Get to know the
Onyx® Genome Engineering instrument.

Generate CRISPR libraries at the push of a button.

The Onyx Digital Genome Engineering Instrument automates all laboratory aspects of your large-scale, parallel genome engineering experiments. From cell transformation and genome editing to cell growth and recovery, bacterial genetic engineering at the push of a button.

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Fast and Easy

Start a whole genome engineering run in just 30 mins: install the ready-to-use consumables, push go and walk away. It doesn’t get any easier!

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Fool Proof

The Onyx automatically reads the consumables’ barcodes and downloads the corresponding protocol ensuring every instrument run is set up for success.

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Fully Automated

From beginning to end, the single, integrated benchtop system performs every step of the engineering process while providing real-time monitoring.

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Unmatched Throughout

In only 2 to 4 days, the Onyx instrument provides cell-type normalization across millions of cells, generating cell libraries with thousands of precise edits.

Bob Van Hove, Program Director, Ginkgo Bioworks, Inc.

I’m really surprised at just how much time we save and money we save creating libraries with Onyx”

Take a look inside the Onyx instrument.

Watch how the innovative Onyx instrument precisely manages all aspects of a genome engineering experiment from consumable initialization to cell outgrowth. All steps are performed inside the consumables to ensure easy clean up, eliminate cross contamination, and provide worry-free instrument maintenance.


Generate any library at the push of a button.

The Onyx gives you the flexibility and scalability to develop virtually limitless libraries. Create insertions, deletions, substitutions, or full saturation mutagenesis, in a single gene, a pathway, or the whole genome.