Democratizing genome engineering
Inspired by the biological diversity found on the island of Madagascar, the MADzyme™ nucleases have improved features over commonly used Cas9 nucleases, such as different PAM recognition sequences and cutting efficiencies, fewer off-target effects, reduced size and differing enzyme kinetics.
We developed and publicly released the MAD7 nuclease, the first of the MADzyme nucleases, to promote widespread adoption of CRISPR tools in academic and commercial settings. The MAD7 nuclease has already been shown to be effective in microbial, plant, fish, and mammalian (including human) systems. Go ahead and try it, the MAD7 nuclease is royalty-free for both academic and commercial research and development use.