Democratizing genome engineering
Inspired by the biological diversity found on the island of Madagascar, the MADzyme™ nucleases have improved features over commonly used CRISPR-Cas9 nucleases, such as different PAM recognition sequences and cut efficiencies, fewer off-target effects, reduced sizes and differing enzyme kinetics.
We developed and publicly released the MAD7™ nuclease, the first of the MADzyme nucleases, to promote widespread adoption of CRISPR tools in academic and commercial settings. The MAD7 nuclease has already been shown to be effective in microbial, plant, fish and mammalian systems. Go ahead and try it, the MAD7 nuclease is royalty-free for both academic and commercial research and development use.